O1383

Oleic acid

BioReagent, suitable for cell culture

• Synonim(y): cis-9-Octadecenoic acid, Elainic acid
• Wzór liniowy: CH₃(CH₂)₇CH=CH(CH₂)₇COOH
• Numer CAS: 112-80-1
• Masa cząsteczkowa: 282.46
• Beilstein: 1726542
• Numer WE: 204-007-1
• Numer MDL: MFCD00064242
• Kod UNSPSC: 12352211
• Identyfikator substancji w PubChem: 24897941
• NACRES: NA.75

Właściwości

• pochodzenie biologiczne: palm oil
• ciśnienie pary: 1 mmHg ( 176 °C)
• linia produktu: BioReagent
• Próba: ≥99% (GC)
• Postać: viscous liquid
• metody: cell culture | mammalian: suitable
• współczynnik refrakcji: n20/D 1.459 (lit.)
• tw: 194-195 °C/1.2 mmHg (lit.)
• mp: 13-14 °C (lit.)
• rozpuszczalność: ethanol: soluble
• gęstość: 0.89 g/mL at 25 °C (lit.); 0.89 g/mL at 25 °C (lit.)
• temp. przechowywania: −20°C
• ciąg SMILES: CCCCCCCC\C=C/CCCCCCCC(O)=O
• InChI: 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
• Klucz InChI: ZQPPMHVWECSIRJ-KTKRTIGZSA-N
• informacje o genach: human ... SOAT1(6646) , SOAT2(8435)

Opis

Opis ogólny

Oleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand.

Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state. Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.

Zastosowanie

Oleic acid has been used:

• in fatty acid oxidation rate experiments in myotubes and in Sirt1 enzyme assay
• to determine quantitatively its effect on lipid droplets by optical diffraction tomography
• as a fatty acid source in the medium for primary hepatocyte culture

Opakowanie

Sealed ampule.

Przestroga

Unsaturated fatty acids are subject to oxidation and peroxidation. Consider complexed fatty acid supplements.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Środki ochrony indywidualnej: Eyeshields, Gloves, type ABEK (EN14387) respirator filter