N3911

NBI 27914

≥98% (HPLC)

• Synonim(y): 5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine
• Wzór empiryczny (zapis Hilla): C₁₈H₂₀Cl₄N₄
• Numer CAS: 184241-44-9
• Masa cząsteczkowa: 434.19
• NACRES: NA.77
• PubChem Substance ID: 24278425
• UNSPSC Code: 12352200
• MDL number: MFCD05662281
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL at 60 °C, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
• InChI: 1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
• InChI key: KNADXBVKFAUMCR-UHFFFAOYSA-N
• Gene Information: human ... CRHR1(1394)

Opis

Application

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:

• to study its effects on steroidogenic gene expression in GD15 mouse testis
• to study its effects on amyloid β production
• to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Biochem/physiol Actions

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves