N194

NS-398

≥98% (HPLC), solid

• Synonim(y): N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
• Wzór empiryczny (zapis Hilla): C₁₃H₁₈N₂O₅S
• Numer CAS: 123653-11-2
• Masa cząsteczkowa: 314.36
• NACRES: NA.77
• PubChem Substance ID: 24897540
• UNSPSC Code: 12352200
• MDL number: MFCD00882995
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• mp: 127-128 °C
• solubility: DMSO: >5 mg/mL, H₂O: insoluble
• SMILES string: CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O
• InChI: 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
• InChI key: KTDZCOWXCWUPEO-UHFFFAOYSA-N
• Gene Information: human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743) ; mouse ... Ptgs2(19225)

Opis

Application

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:

• the cardiac rate in zebrafish embryos[1]
• apoptosis and hypoxia/reoxygenation in rat cardiomyocytes[2]
• the lipopolysaccharide (LPS) induced anorexia in rats[3]

Biochem/physiol Actions

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family.[4] It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.[4][5]

Selective cyclooxygenase-2 (COX-2) inhibitor.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)