N1790

Naftifine hydrochloride

• Synonim(y): Naftifine HCL
• Wzór empiryczny (zapis Hilla): C₂₁H₂₁N · HCl
• Numer CAS: 65473-14-5
• Masa cząsteczkowa: 323.86
• NACRES: NA.76
• PubChem Substance ID: 329818590
• UNSPSC Code: 51102829
• MDL number: MFCD00059047

Właściwości

• assay: ≥99%
• Quality Level: 200
• form: powder
• solubility: ethanol: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, fungi, yeast
• mode of action: cell wall synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• InChI key: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Opis

Application

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis[1].

Biochem/physiol Actions

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion[2]. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells[1].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable