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Dokumenty

N1790

Sigma-Aldrich

Naftifine hydrochloride

Synonim(y):

Naftifine HCL

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Wszystkie zdjęcia(3)

About This Item

Wzór empiryczny (zapis Hilla):
C21H21N · HCl
Numer CAS:
65473-14-5
Masa cząsteczkowa:
323.86
Numer MDL:
MFCD00059047
Kod UNSPSC:
51102829
Identyfikator substancji w PubChem:
329818590
NACRES:
NA.76

Próba

≥99%

Postać

powder

rozpuszczalność

ethanol: soluble 50 mg/mL

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
fungi
yeast

Tryb działania

cell wall synthesis | interferes
enzyme | inhibits

temp. przechowywania

2-8°C

ciąg SMILES

Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23

InChI

1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;

Klucz InChI

OLUNPKFOFGZHRT-YGCVIUNWSA-N

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Zastosowanie

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Działania biochem./fizjol.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

nwg

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Lawrence Charles Parish et al.
Journal of drugs in dermatology : JDD, 10(11), 1282-1288 (2011-11-05)
Naftifine HCl 2% cream (NAFT-2) is a topical allylamine antifungal agent under development in the United States. This randomized, double-blind, vehicle-controlled, phase 3 trial evaluated the efficacy and safety of two weeks of NAFT-2 treatment in subjects with tinea pedis.
Maite Uzqueda et al.
Pharmaceutical research, 23(5), 980-988 (2006-05-23)
Naftifine (NF) is an antifungal drug poorly soluble in basic aqueous solutions. Complexation with cyclodextrins (CDs) improves the physicochemical characteristics of many drugs. The aim of this work is to characterize the interactions between NF and alpha-CD, beta-CD, hydroxypropylbeta-CD, methylbeta-CD
Aditya K Gupta et al.
Journal of cutaneous medicine and surgery, 12(2), 51-58 (2008-03-19)
Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also
Michael H Gold et al.
Journal of drugs in dermatology : JDD, 11(4), 514-518 (2012-03-29)
Topical antifungal treatment is a mainstay of therapy for Seborrehic Dermatitis (SD). Although the amidazole and ciclopyridine antifungals have been extensively studied, few clinical efficacy data are available for topical allylamine therapy in SD. The objective of this open-label exploratory
Ruifeng Zhang et al.
Medical mycology, 49(1), 90-93 (2010-07-29)
We report a rare case of kerion celsi of the scalp caused by Microsporum gypseum in a boy 1 month after he received dermatoplasty for a scalp injury from a road accident. Species identification was performed by observation of morphologic
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