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M8822

MEK1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonim(y):

MAP2K1, MAPKK1, MKK1, PRKMK1

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 μg
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2280,00 zł

Informacje o tej pozycji

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
276-374 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

2280,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomóc

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

276-374 nmol/min·mg

mol wt

~69 kDa

UniProt accession no.

P31938

shipped in

dry ice

storage temp.

−70°C

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Ta pozycja
M1198SRP5047SRP5294
MEK1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M8822

MEK1, active, GST tagged human

MEK2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M1198

MEK2, active, GST tagged human

MEKK1 (664-1512), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5047

MEKK1 (664-1512), active, GST tagged human

MEKK6, active, GST tagged human PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5294

MEKK6, active, GST tagged human

specific activity

276-374 nmol/min·mg

specific activity

190-258 nmol/min·mg

specific activity

697-943 nmol/min·mg

specific activity

8-12 nmol/min·mg

Gene Information

human ... Map2k1(26395)

Gene Information

human ... MAP2K2(5605)

Gene Information

human ... Map3K1(4214)

Gene Information

human ... MAP3K6(9064)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

mol wt

~69 kDa

mol wt

~71 kDa

mol wt

~155 kDa

mol wt

~67 kDa

General description

Mitogen activated protein kinase/ERK kinase (MEK)1 is a hydrophilic non-receptor protein and is a member of dual specificity protein kinase family. It is ubiquitously expressed.[1] MAP2K1 is encoded by the gene mapped to human chromosome 15q22.31.[2]

Application

MEK1, active, GST tagged human has been used to induce kinase reactions in in vitro mitogen activated protein kinase/ERK kinase (MEK)1 kinase assay.[3] It has also been used to activate extracellular-signal-regulated kinase 2 (ERK2) by phosphorylation.[4]

Biochem/physiol Actions

Mitogen activated protein kinase/ERK kinase (MEK)1/2 catalyzes the phosphorylation of tyrosine and then threonine in extracellular-signal-regulated kinase1/2. As an essential component of RAS−RAF−MEK−ERK signaling pathway (MAP kinase signaling cascade), it is involved in the regulation of apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation.[1] Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative diseases such as cancer.[5]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
SLCH2390
SLCG4662
SLCF5340
SLBX2490
SLBR9041V

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Odwiedź Bibliotekę dokumentów

Clément Danis et al.
Journal of visualized experiments : JoVE, (118) (2017-01-07)
Aggregates of the neuronal Tau protein are found inside neurons of Alzheimer's disease patients. Development of the disease is accompanied by increased, abnormal phosphorylation of Tau. In the course of the molecular investigation of Tau functions and dysfunctions in the
Stefanie Galbán et al.
Molecular cancer therapeutics, 16(11), 2340-2350 (2017-08-05)
Responses to targeted therapies frequently are brief, with patients relapsing with drug-resistant tumors. For oncogenic MEK and BRAF inhibition, drug resistance commonly occurs through activation of PI3K/AKT/mTOR signaling and immune checkpoint modulation, providing a robust molecular target for concomitant therapy.
Robert Roskoski
Biochemical and biophysical research communications, 417(1), 5-10 (2011-12-20)
MEK1 and MEK2 are related protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation. Moreover, oncogenic
Pinar Oztas et al.
American journal of clinical dermatology, 8(2), 113-116 (2007-04-13)
Punctate palmoplantar keratoderma (PPPK) is a rare entity with an estimated prevalence rate of about 1.17 per 100,000. The exact etiology of the disorder is not known but a dual influence of genetic and environmental factors may trigger the disease.
Hung Huynh et al.
BMC gastroenterology, 3, 19-19 (2003-08-09)
Hepatocellular carcinoma (HCC) is one of the most common malignancies in South East Asia. Although activation of the MEK-MAPK is often associated with cellular growth, the role of MEK-MAPK in growth and survival of hepatocarcinoma cells has not been established.
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SKUNUMER GTIN
M8822-10UG04061837756092

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