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M5435
6-Methyl-2-(phenylethynyl)pyridine hydrochloride
≥98% (HPLC)
Synonim(y):
MPEP hydrochloride
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 446,00 zł 379,10 zł | |
| 25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1600,00 zł 1360,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C14H11N · HCl
Numer CAS:
Masa cząsteczkowa:
229.70
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
379,10 zł
Cena katalogowa446,00 złZaoszczędź 15%Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócQuality Level
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
SMILES string
Cl.Cc1cccc(n1)C#Cc2ccccc2
InChI
1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChI key
PKDHDJBNEKXCBI-UHFFFAOYSA-N
Gene Information
human ... GRIN2B(2904), GRM5(2915)
rat ... Grm5(24418)
General description
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.
Application
6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).
Biochem/physiol Actions
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).
Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility DMSO: 10 mg/mL, clear | solubility H2O: 5 mg/mL (clear solution) | solubility H2O: 20 mg/mL, clear | solubility H2O: 20 mg/mL, clear |
| color off-white to light tan | color white to beige | color white to beige | color white to beige |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Produkty
DISCOVER Bioactive Small Molecules for Neuroscience
Human GRIN2B variants in neurodevelopmental disorders
Hu C, et al.
Journal of Pharmacological Sciences, 132(2), 115-121 (2016)
Li Rebekah Feng et al.
Translational psychiatry, 8(1), 110-110 (2018-06-01)
Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients. We employed Fisher
José Luis Albasanz et al.
ACS chemical neuroscience, 7(12), 1690-1697 (2016-09-17)
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| M5435-5MG | 04061834059950 |
| M5435-25MG | 04061834059943 |