M3778

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

Name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Brand: SIGMA
Price: 568 PLN

≥97% (GC), MAO-A inhibitor, powder

Synonim(y):

Clorgyline

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50 MG

568,00 zł

100 MG

840,00 zł

500 MG

2890,00 zł

568,00 zł

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Wzór empiryczny (zapis Hilla):

C₁₃H₁₅Cl₂NO · HCl

Numer CAS:

17780-75-5

Masa cząsteczkowa:

308.63

NACRES:

NA.77

PubChem Substance ID:

24278179

UNSPSC Code:

12352116

EC Number:

241-760-5

MDL number:

MFCD00052012

Assay:

≥97% (GC)

Form:

powder

Quality level:

100

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Nazwa produktu

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride, ≥97% (GC)

InChI key

BBAZDLONIUABKI-UHFFFAOYSA-N

InChI

1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H

SMILES string

Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

assay

≥97% (GC)

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

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Ta pozycja	P8511	E2895	A3085
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride	Sigma-Aldrich P8511 trans-2-Phenylcyclopropylamine hydrochloride	Sigma-Aldrich E2895 (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide	Sigma-Aldrich A3085 5-(N-Ethyl-N-isopropyl)amiloride
form powder	form powder	form powder	form powder
assay ≥97% (GC)	assay ≥97% (TLC)	assay ≥98%	assay ≥98% (TLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility ethanol: 50 mg/mL, clear to slightly hazy	solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
Gene Information human ... MAOA(4128) rat ... Maoa(29253), Maob(25750)	Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information -	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Application

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

in MAO-A biochemical assay[1]
to study its effects on the transit of serotonin (5-HT) in the human placenta explants[2]
to study its effects on human prostate cancer cells[3]

Biochem/physiol Actions

MAO-A inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301,H312 + H332

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.

Tamara Maes et al.

Cancer cell, 33(3), 495-511 (2018-03-06)

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic

Serotonin synthesis and metabolism-related molecules in a human prostate cancer cell line.

Toshiaki Shinka et al.

Oncology letters, 2(2), 211-215 (2011-03-01)

Prostate cancer is one of the most common tumors in males and its incidence is steadily increasing worldwide. Serotonin or 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter that mediates a wide variety of physiological effects. An increase in the number of

Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities.

J C Shih et al.

Journal of neural transmission. Supplementum, 52, 1-8 (1998-06-13)

MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies.

Melissa D'Ascenzio et al.

Journal of enzyme inhibition and medicinal chemistry, 30(6), 908-919 (2015-03-26)

Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B

Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.

H Inoue et al.

The Journal of pharmacology and experimental therapeutics, 291(2), 856-864 (1999-10-19)

In an attempt to provide a better understanding of the scope and limitations of animal models used in some drug development programs and to further our understanding of potential metabolic bioactivation reactions, we have undertaken studies to profile the monoamine

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Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

≥97% (GC), MAO-A inhibitor, powder

Wybierz wielkość

M3778-50MG

568,00 zł

Informacje o tej pozycji

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InChI key

InChI

SMILES string

assay

form

solubility

storage temp.

Quality Level

Gene Information

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Opis

Application

Biochem/physiol Actions

Features and Benefits

Informacja o środkach bezpieczeństwa

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Klasa składowania

wgk

ppe

Dokumentacja

Certyfikaty analizy (CoA)

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