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K1639

K-252a

Name: K-252a
Brand: SIGMA

from Nonomuraea longicatena, ≥98% (HPLC)

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₇H₂₁N₃O₅

Numer CAS:

99533-80-9

Masa cząsteczkowa:

467.47

NACRES:

NA.77

PubChem Substance ID:

24896210

UNSPSC Code:

12352200

MDL number:

MFCD00161522

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

200

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Właściwości

biological source

Nonomuraea longicatena

Quality Level

200

assay

≥98% (HPLC)

form

solid

solubility

DMF: 1 mg/mL, DMSO: 1 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

Gene Information

human ... NTRK1(4914)
rat ... Prkca(24680)

Opis

Application

K-252a has been used:

as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats[1]
as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)[2]
as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly[3]

Biochem/physiol Actions

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC₅₀ values between 3 and 25nM[3] and the neurotrophin receptor[2]-tropomyosin receptor kinase.[1]

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Ta pozycja	420321	260585	474422
Sigma-Aldrich K1639 K-252a	Sigma-Aldrich 420321 KT5823	Sigma-Aldrich 260585 5′-Deoxy-5′-methylthioadenosine	Sigma-Aldrich 474422 4-Methylumbelliferyl-α-D-galactopyranoside
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form solid
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMF: 1 mg/mL, DMSO: 1 mg/mL	solubility DMSO: 1 mg/mL, DMF: soluble	solubility DMF: 25 mg/mL, DMSO: soluble	solubility DMF: 50 mg/mL
shipped in dry ice	shipped in ambient	shipped in ambient	shipped in ambient

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000445766

0000258922

14150301

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Powiązane treści

Data Sheet - K1639

Datasheet

Effects of Cord Blood Serum (CBS) on viability of retinal Müller glial cells under in vitro injury.

Carmen Ciavarella et al.

PloS one, 15(6), e0234145-e0234145 (2020-06-05)

Oxidative stress and inflammation determine retinal ganglion cell degeneration, leading to retinal impairment and vision loss. Müller glial cells regulate retinal repair under injury, through gliosis. Meanwhile, reactive gliosis can turn in pathological effects, contributing to neurodegeneration. In the present

Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.

Kalsoom Sughra et al.

PloS one, 5(9), e12683-e12683 (2010-09-22)

I-kappa B kinase 2 (IKK2 or IKK-beta) is one of the most crucial signaling kinases for activation of NF-kappa B, a transcription factor that is important for inflammation, cell survival and differentiation. Since many NF-kappa B activating pathways converge at

The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.

Alla Khodorova et al.

Neuroscience, 340, 384-397 (2016-11-09)

The p75 neurotrophin receptor (p75NTR) and its activation of the sphingomyelin signaling cascade are essential for mechanical hypersensitivity resulting from locally injected nerve growth factor (NGF). Here the roles of the same effectors, and of the tropomyosin receptor kinase A

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
K1639-100UG	04061833868058

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