I5784

Ibandronate sodium salt

≥97% (NMR), solid

• Synonim(y): (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat
• Wzór empiryczny (zapis Hilla): C₉H₂₂NNaO₇P₂
• Numer CAS: 138844-81-2
• Masa cząsteczkowa: 341.21
• Numer MDL: MFCD07197214
• Kod UNSPSC: 41106300
• Identyfikator substancji w PubChem: 329815388
• NACRES: NA.77

Właściwości

• Próba: ≥97% (NMR)
• Postać: solid
• warunki przechowywania: protect from light
• kolor: white
• rozpuszczalność: H₂O: >10 mg/mL
• inicjator: Roche
• temp. przechowywania: 2-8°C
• ciąg SMILES: [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
• Klucz InChI: LXLBEOAZMZAZND-UHFFFAOYSA-M
• informacje o genach: human ... FDPS(2224)

Opis

Zastosowanie

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.

Działania biochem./fizjol.

Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC₅₀ = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

Cechy i korzyści

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable