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I1286

Sigma-Aldrich

Icariin

≥94% (HPLC)

Synonim(y):

4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside

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100 MG
686,00 zł
1 G
4020,00 zł

686,00 zł

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100 MG
686,00 zł
1 G
4020,00 zł

About This Item

Wzór empiryczny (zapis Hilla):
C33H40O15
Numer CAS:
489-32-7
Masa cząsteczkowa:
676.66
Numer MDL:
MFCD00210516
Kod UNSPSC:
12352205
Identyfikator substancji w PubChem:
329815347
NACRES:
NA.25

686,00 zł

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Poproś o zamówienie zbiorcze

Próba

≥94% (HPLC)

kolor

light yellow to yellow

rozpuszczalność

DMSO: 50 mg/mL, clear, colorless to dark yellow

Zastosowanie

metabolomics
vitamins, nutraceuticals, and natural products

temp. przechowywania

room temp

ciąg SMILES

COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2

InChI

1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

Klucz InChI

TZJALUIVHRYQQB-XLRXWWTNSA-N

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Opis ogólny

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.[1]

Zastosowanie

Icariin has been used:
  • in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats[2]
  • to test its analgesic effects on lower back pain (LBP) in rats[3]
  • as a potential treatment in osteoporosis condition in rats[4]
  • to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes[5]
  • as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells[6]

Działania biochem./fizjol.

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.
Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system.[1] It elicits anti-aging properties in unfertilized oocytes against age-related damage.[7] Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model.[8] It also serves as an excellent antidiabetic[9] and anti-atherosclerotic agent.[10] Icariin is an excellent anti-cancer agent.[1]
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number
WXBF3544V
WXBF2114V
WXBD8605V
WXBD2828V
MKCJ1712

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Melatonin A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.

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Hesperetin phyproof® Reference Substance

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Sennoside A analytical standard

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Puerarin analytical standard

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Berberine chloride form

Sigma-Aldrich

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Berberine chloride form

Curcumin, Curcuma longa L. A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (IC₅₀ = 52 µM).

Sigma-Aldrich

239802

Curcumin, Curcuma longa L.

Xin Zhang et al.
Phytotherapy research : PTR, 28(4), 498-509 (2013-07-05)
Traditional Chinese medicines have been recommended for bone regeneration and repair for thousands of years. Currently, the Herba Epimedii and its multi-component formulation are the attractive native herbs for the treatment of osteoporosis. Icariin, a typical flavonol glycoside, is considered
Ying Pan et al.
Psychoneuroendocrinology, 38(1), 122-134 (2012-06-06)
Epidemiological evidence demonstrates the neuroendocrine link between stress, depression and diabetes. This study observed glucose intolerance of rats exposed to chronic unpredictable mild stress (CUMS) in oral glucose tolerance test (OGTT). CUMS procedure significantly up-regulated corticotropin-releasing factor (CRF)-related peptide urocortin
Lijuan Yang et al.
Journal of ethnopharmacology, 145(3), 715-721 (2012-12-25)
Epimedium brevicornum Maxim has long been used for the treatment of osteoporosis in China and other Asian countries. However, the mechanism behind the antiosteoporotic activity of this medicinal plant is not fully understood. The present study was designed to investigate
Wangkheirakpam Ramdas Singh et al.
European journal of pharmacology, 858, 172466-172466 (2019-06-21)
Icariin is a flavonoid from plant belonging to the genus Epimedium, commonly known as Horny goat weed or Yin Yang Huo. The compound possesses multiple biological activities which are associated with the modulation of many signalling pathways, like NF-κB, Erk-p38-JNK
Jae-Wook Yoon et al.
Animal bioscience, 34(4), 546-557 (2020-08-12)
If fertilization does not occur within a specific period, the quality of unfertilized oocytes in the oviduct (in vivo aging) or in culture (in vitro aging) will deteriorate over time. Icariin (ICA), found in all species of Epimedium herbs, has
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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