The solubility of this item is 1mg/ml as mentioned on the COA.
Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdf
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H7640-1MG
2110,00 zł
H7640-5MG
2910,00 zł
H7640-10MG
5100,00 zł
2110,00 zł
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Pozwól nam pomócNazwa produktu
Heparan sulfate sodium salt from bovine kidney,
storage temp.
2-8°C
Powiązane kategorie
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Ta pozycja | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
Application
Heparan sulfate sodium salt from bovine kidney has been used:
- to investigate its effect on proliferation of B cells[1]
- to monitor its role on eye development in E5 embryonic cells
- to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot
Biochem/physiol Actions
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer?s disease
Zhang GL, et al.
BioMed Research International, 2014(6), 555-571 (2014)
Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression
Nagarajan A, et al.
Frontiers in Endocrinology, 9(4), 203-231 (2018)
Change in embryonic eye size and retinal cell proliferation following intravitreal injection of glycosaminoglycans
Halfter W
Investigative Ophthalmology & Visual Science, 49(8), 3289-3298 (2008)
Mechanism of fibronectin binding to human trabecular meshwork exosomes and its modulation by dexamethasone
Dismuke WM, et al.
Testing, 11(10), e0165326-e0165326 (2016)
Y Tanaka et al.
The Journal of experimental medicine, 184(5), 1987-1997 (1996-11-01)
Leukocyte migration from circulation into tissue depends on leukocyte integrin-mediated adhesion to endothelium, but integrins cannot function until activated. However, it remains to be understood how tumor cells adhere to endothelium and infiltrate into underlying tissue. We studied mechanisms of
Produkty
Dowiedz się więcej o glikozoaminoglikanach i proteoglikanach, w tym o strukturze glikozoaminoglikanów (GAG), różnych typach GAG i ich funkcjach.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.
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