G6771

Growth Hormone Releasing Factor Fragment 1-29 amide human

Name: Growth Hormone Releasing Factor Fragment 1-29 amide human
Brand: SIGMA
Price: 3010 PLN

≥97% (HPLC)

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1 MG

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₄₉H₂₄₆N₄₄O₄₂S

Numer CAS:

86168-78-7

Masa cząsteczkowa:

3357.88

NACRES:

NA.32

PubChem Substance ID:

329799954

UNSPSC Code:

51111800

MDL number:

MFCD00076559

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InChI

1S/C149H246N44O42S/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158/h22-24,32-33,39-46,72-82,88-108,115-118,194-199H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,200)(H2,154,201)(H2,155,202)(H2,156,208)(H,166,213)(H,167,212)(H,168,221)(H,169,229)(H,170,203)(H,171,230)(H,172,209)(H,173,214)(H,174,215)(H,175,225)(H,176,222)(H,177,233)(H,178,210)(H,179,216)(H,180,217)(H,181,223)(H,182,231)(H,183,218)(H,184,232)(H,185,234)(H,186,235)(H,187,219)(H,188,224)(H,189,226)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI key

WGWPRVFKDLAUQJ-MITYVQBRSA-N

assay

≥97% (HPLC)

UniProt accession no.

P01286, Q02643

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GHRH(2691), GHRHR(2692)

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Ta pozycja	G8147	P1319	SCP0161
Sigma-Aldrich G6771 Growth Hormone Releasing Factor Fragment 1-29 amide human	Sigma-Aldrich G8147 Glucagon-Like Peptide I Amide Fragment 7-36 human	Sigma-Aldrich P1319 Thyrotropin releasing hormone	Sigma-Aldrich SCP0161 [D-Ala²]-Growth Hormone Releasing Factor 1-29 amide human
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level -
UniProt accession no. P01286, Q02643	UniProt accession no. P01275	UniProt accession no. P20396, P21761, P34981	UniProt accession no. -
Gene Information human ... GHRH(2691), GHRHR(2692)	Gene Information human ... GCG(2641)	Gene Information human ... TRH(7200), TRHR(7201) mouse ... Trhr(22045)	Gene Information -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

GHRH/GRH (growth hormone releasing hormone) is an endocrine peptide hormone composed of 44 amino acids[1]† It exists in two forms in the hypothalamus, namely GRH(1-44)-NH2 and GRH(1-40)-OH. However, the full biological functionality of this hormone resides in the first 29 amino acids itself. GRH(1-29)-NH2 is a C-terminal shortened peptide produced from GHRH.[2]

Biochem/physiol Actions

Amidated GRF fragment that is equipotent to GRF in releasing somatotropin from anterior pituitary.

GHRH/GRH (growth hormone releasing hormone) is released from the hypothalamus from where it reaches the anterior pituitary and binds to its receptor, thus, eventually leading to the release of GH (growth hormone) into the plasma.[1][2]

Other Notes

Lyophilized from 0.1% TFA in H2O

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH).

Burcu Ayhan-Sahin et al.

PloS one, 17(1), e0260144-e0260144 (2022-01-22)

Growth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids. GHRH (NH2 1-29) peptide antagonists inhibit the growth of prostate, breast, ovarian, renal, gastric, pancreatic cancer in vitro and

GHRH antagonist when combined with cytotoxic agents induces S-phase arrest and additive growth inhibition of human colon cancer.

Ferenc G Rick et al.

Cell cycle (Georgetown, Tex.), 11(22), 4203-4210 (2012-10-26)

Treatment of colon cancer with an antagonist of growth hormone-releasing hormone (GHRH), JMR-132, results in a cell cycle arrest in S-phase of the tumor cells. Thus, we investigated the effect of JMR-132 in combination with S-phase-specific cytotoxic agents, 5-FU, irinotecan

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

Lucie Jetté et al.

Endocrinology, 146(7), 3052-3058 (2005-04-09)

In vivo bioconjugation to the free thiol on Cys34 of serum albumin by a strategically placed reactive group on a bioactive peptide is a useful tool to extend plasma half-life. Three maleimido derivates of human GH-releasing factor (hGRF)(1-29) were synthesized

GHRH antagonist inhibits focal adhesion kinase (FAK) and decreases expression of vascular endothelial growth factor (VEGF) in human lung cancer cells in vitro.

Agnieszka Siejka et al.

Peptides, 37(1), 63-68 (2012-07-24)

Lung cancers which show increased vascularization and high microvessel density are considered highly metastatic and with poor prognosis. Growth hormone releasing hormone (GHRH) antagonists are anticancer agents without adverse events in lung cancer tumor models. In the present study we

Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases.

Ferenc G Rick et al.

Proceedings of the National Academy of Sciences of the United States of America, 109(5), 1655-1660 (2012-02-07)

The management of castration-resistant prostate cancer (CRPC) presents a clinical challenge because of limitations in efficacy of current therapies. Novel therapeutic strategies for the treatment of CRPC are needed. Antagonists of hypothalamic growth hormone-releasing hormone (GHRH) inhibit growth of various

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Growth Hormone Releasing Factor Fragment 1-29 amide human