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F4765
Fluphenazine dihydrochloride
Synonim(y):
4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C22H26F3N3OS · 2HCl
Numer CAS:
Masa cząsteczkowa:
510.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-674-1
MDL number:
SMILES string
Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
InChI
1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
InChI key
MBHNWCYEGXQEIT-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), HRH1(3269)
General description
Fluphenazine may be useful for the treatment of schizophrenia.
Application
Fluphenazine dihydrochloride has been used:
- to study its effects as a drug on glioblastoma (GBM) cells
- in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
- to study its exposure effects on learning and memory in adult rats
Biochem/physiol Actions
D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1A
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Yaakov G, et al.
Nature ecology & evolution, 1(1), 0016-0016 (2017)
Principles of Psychopharmacology for Mental Health Professionals (2006)
G Cai et al.
Molecular pharmacology, 56(5), 989-996 (1999-10-26)
The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| F4765-1G | 04061825982250 |
| F4765-5G | 04061832090832 |