D6196

Dimebon dihydrochloride hydrate

≥98% (HPLC)

• Synonim(y): 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate
• Wzór empiryczny (zapis Hilla): C₂₁H₂₅N₃ · 2HCl · xH₂O
• Numer CAS: 97657-92-6
• Masa cząsteczkowa: 392.37 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329798824
• UNSPSC Code: 12352200
• MDL number: MFCD17215933
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
• InChI: 1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
• InChI key: QQHQMWVYYVVAOV-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable