This product is soluble in water, however, the concentration has not been determined. Various sources state this chemical can be solubilized in water at greater than 1 mg/mL.
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T2705
Topotecan hydrochloride hydrate
≥98% (HPLC and enzymatic), powder, topoisomerase I inhibitor
Synonim(y):
9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate, NSC-609669 hydrochloride hydrate, SKF-104864A hydrochloride hydrate, hycamptamine hydrochloride hydrate
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
10 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 460,00 zł |
50 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1740,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C23H23N3O5 · xHCl · yH2O
Numer CAS:
Masa cząsteczkowa:
421.45 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC and enzymatic)
Form:
powder
Storage condition:
desiccated, protect from light
460,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Topotecan hydrochloride hydrate, ≥98% (HPLC and enzymatic)
Quality Segment
assay
≥98% (HPLC and enzymatic)
form
powder
storage condition
desiccated, protect from light
color
yellow
solubility
DMSO: ≥20 mg/mL
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
[n]21c(cc5c([c]2=O)COC(=O)[C@]5(O)CC)c3nc4c(cc3C1)c(c(cc4)O)CN(C)C
InChI
1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChI key
UCFGDBYHRUNTLO-QHCPKHFHSA-N
Gene Information
human ... TOP1MT(116447)
Application
Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions1. It has also been used for in vitro apoptosis assays in PA317 cells2.
Biochem/physiol Actions
Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
Features and Benefits
This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
This product is soluble in water, however, the concentration has not been determined. Various sources state this chemical can be solubilized in water at greater than 1 mg/mL.
Topotecan hydrochloride hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.
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Ta pozycja | |||
|---|---|---|---|
| description ≥98% (HPLC and enzymatic) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC), solid |
| assay ≥98% (HPLC and enzymatic) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition protect from light, desiccated | storage condition desiccated | storage condition - | storage condition - |
| solubility DMSO: ≥20 mg/mL | solubility DMSO: >10 mg/mL | solubility H2O: ≥10 mg/mL | solubility H2O: >5 mg/mL |
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Good day, Please advise whether or not this drug is water soluble? The SDS sheet indicates that it is however the label indicates that it should be dissolved in DMSO. Thank you.
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