D4434

Dichloromethylenediphosphonic acid disodium salt

osteoclastic activity inhibitor, powder

• Synonim(y): Cl₂MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
• Wzór liniowy: CH₂O₆Cl₂Na₂P₂
• Numer CAS: 22560-50-5
• Masa cząsteczkowa: 288.86
• NACRES: NA.77
• PubChem Substance ID: 24278371
• UNSPSC Code: 12352106
• EC Number: 245-078-9
• MDL number: MFCD01632786
• Form: powder

Właściwości

• Nazwa produktu: Dichloromethylenediphosphonic acid disodium salt,
• form: powder
• Quality Segment: 300
• solubility: water: 49.00-51.00 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
• InChI: 1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: HJKBJIYDJLVSAO-UHFFFAOYSA-L
• Gene Information: rat ... Man2a1(25478), Si(497756)

Opis

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma.[1][2] When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver.[3] Found also to inhibit collagenase and matrix metalloproteinase1.[4]

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)