C8035
Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse
clone CS-56, ascites fluid
Synonim(y):
Chondroitin Sulfate Antibody, Chondroitin Sulfate Antibody - Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse, Cs56 Antibody
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
ascites fluid
rodzaj przeciwciała
primary antibodies
klon
CS-56, monoclonal
reaktywność gatunkowa
chicken, bovine, mouse, human, pig, rabbit, rat
metody
indirect immunofluorescence: 1:200 using bovine mammary gland epithelial (BMGE) cells
microarray: suitable
izotyp
IgM
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... ACAN(176)
mouse ... Acan(11595)
rat ... Acan(58968)
Opis ogólny
Chondroitin sulfate is a linear polysaccharide composed of alternating disaccharide glucuronic acid and N-acetylgalactosamine. It contains proteoglycan (PG) of the extracellular matrix (ECM). Monoclonal Anti-Chondroitin Sulfate (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
This product can be found as purified product that was produced using cell culture hybridoma (SAB4200696)
This product can be found as purified product that was produced using cell culture hybridoma (SAB4200696)
Specyficzność
The antibody has been reported to be specific for the glycosaminoglycan (GAG) portion of native chondroitin sulfate proteoglycan (CSPG). The antibody reacts specifically with chondroitin sulfate types A and C but not with type B (dermatan sulfate), and may be used for localization of chondroitin sulfate in tissues and cultured fibroblasts.
Immunogen
Ventral membranes of chicken gizzard fibroblasts
Zastosowanie
Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse was used:
- in immunohistochemistry as primary antibody to study of spinal cords and brain cryosections.
- in ELISA and western blot for purification of soluble forms of myelin-associated glycoprotein (MAG) and neural cell adhesion molecule (N-CAM).
- in flow cytometry studies.
- as primary antisera in a study of TGF-β regulation.
Działania biochem./fizjol.
Chondroitin sulfate is involved in tumor invasion and also plays a vital role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. In Chondroitin sulfate proteoglycan (CSPG), proteoglycan part is involved in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. Chondroitin sulfate is used in osteoarthritis treatment. Upregulation of chondroitin sulfate proteoglycans is observed after neuronal injury. It possess the ability to inhibit axonal regeneration.
Przechowywanie i stabilność
For continuous use, store at 2-8 °C for up to one month.
For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Inne uwagi
This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal
clone CS-56, purified from hybridoma cell culture
SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal
clone CS-56, purified from hybridoma cell culture
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Klienci oglądali również te produkty
PTPσ is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.
Shen Y, et al.
Science, 326(5952) (2009)
Charlotte Rolny et al.
The Journal of biological chemistry, 277(22), 19315-19321 (2002-03-26)
Platelet-derived growth factor (PDGF) induces mitogenic and migratory responses in a wide variety of cells, by activating specific receptor tyrosine kinases denoted the PDGF alpha- and beta-receptors. Different PDGF isoforms bind in a distinct manner to glycosaminoglycans, particularly heparan sulfate.
Z Avnur et al.
Cell, 38(3), 811-822 (1984-10-01)
Chondroitin-sulfate containing proteoglycan (CSPG) of the extracellular matrix (ECM) was visualized in chick tissues and cell cultures with a monoclonal antibody, CS-56. Cultured cells of various origins contained dense punctate layers of CSPG on both the substrate and the cell
R Probstmeier et al.
The Journal of cell biology, 116(4), 1063-1070 (1992-02-01)
To gain insights into the functional role of the molecular association between neural adhesion molecules and extracellular matrix constituents, soluble forms of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM), representing most of the extracellular domains of
Bala T S Susarla et al.
Journal of neurochemistry, 119(4), 868-878 (2011-09-08)
Traumatic injury to the CNS results in increased expression and deposition of chondroitin sulfate proteoglycans (CSPGs) that are inhibitory to axonal regeneration. Transforming growth factor-β (TGF-β) has been implicated as a major mediator of these changes, but the mechanisms through
Produkty
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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