C7698

Cycloheximide

from microbial, ≥94% (TLC)

• Synonim(y): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Wzór empiryczny (zapis Hilla): C₁₅H₂₃NO₄
• Numer CAS: 66-81-9
• Masa cząsteczkowa: 281.35
• Beilstein: 88868
• Numer WE: 200-636-0
• Numer MDL: MFCD00082346
• Kod UNSPSC: 12352111
• Identyfikator substancji w PubChem: 24892981
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: microbial
• Próba: ≥94% (TLC)
• Postać: powder
• kolor: white to off-white
• rozpuszczalność: ethanol: soluble, clear to hazy
• spektrum działania antybiotyku: fungi; yeast
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Klucz InChI: YPHMISFOHDHNIV-FSZOTQKASA-N
• informacje o genach: human ... FKBP1A(2280) , PIN1(5300)

Opis

Opis ogólny

Cycloheximide, also known as Actidione, is a glutarimide antibiotic commonly derived from the bacterium Streptomyces griseus. It acts as a potent inhibitor of protein biosynthesis in eukaryotic cells by disrupting the translocation step during translation, effectively blocking translational elongation. In microbiology, it plays a crucial role as a selection agent for resistant strains of yeast and fungi, proving invaluable in controlled experimental environments.

In cell biology and biochemical research, Cycloheximide showcases a dual nature concerning Apoptosis Induction, inducing or inhibiting apoptosis depending on the cell type. Its rapid and reversible effects make it an ideal choice for studying cellular processes and determining protein half-life. Cycloheximide also finds extensive applications in biomedical research, where it inhibits protein synthesis in eukaryotic cells studied in vitro (outside of organisms) and its effects are rapidly reversed by simply removing it. This makes Cycloheximide a go-to choice for exploring cell biology, biomedical and biochemical research, offering precise control and versatility in experiments.

Zastosowanie

• In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
• It has been used to inhibit translation in mammalian cells.
• It has been used to suppress fungal growth.

Działania biochem./fizjol.

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Cechy i korzyści

• High-quality antibiotic suitable for multiple research applications
• Commonly used in Cell Biology and Biochemical applications

Przechowywanie i stabilność

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.

Inne uwagi

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Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300,H341,H360D,H411
• Zwroty wskazujące środki ostrożności: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges