C1988

Cycloheximide

Biotechnology Performance Certified

• Synonim(y): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Wzór empiryczny (zapis Hilla): C₁₅H₂₃NO₄
• Numer CAS: 66-81-9
• Masa cząsteczkowa: 281.35
• Beilstein: 88868
• Numer WE: 200-636-0
• Numer MDL: MFCD00082346
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 24892457
• NACRES: NA.85

Właściwości

• klasa czystości: Biotechnology Performance Certified
• Formularz: powder
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• rozpuszczalność: ethanol: 50 mg/mL
• spektrum działania antybiotyku: fungi; yeast
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Klucz InChI: YPHMISFOHDHNIV-FSZOTQKASA-N
• informacje o genach: human ... FKBP1A(2280) , PIN1(5300)

Opis

Zastosowanie

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques[1] and activate cumulus-free equine oocytes.[2]

Działania biochem./fizjol.

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation.[3] More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.[4]

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300,H341,H360D,H411
• Zwroty wskazujące środki ostrożności: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges