C6895

Cefaclor

• Synonim(y): 7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
• Wzór empiryczny (zapis Hilla): C₁₅H₁₄ClN₃O₄S
• Numer CAS: 53994-73-3
• Masa cząsteczkowa: 367.81
• UNSPSC Code: 51283701
• NACRES: NA.85
• PubChem Substance ID: 24278331
• EC Number: 258-909-5
• Beilstein/REAXYS Number: 8176092
• MDL number: MFCD00151471

Właściwości

• form: powder or crystals
• Quality Segment: 200
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• SMILES string: N[C@@H](C(=O)N[C@H]1[C@H]2SCC(Cl)=C(N2C1=O)C(O)=O)c3ccccc3
• InChI: 1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
• InChI key: QYIYFLOTGYLRGG-GPCCPHFNSA-N

Opis

General description

Chemical structure: β-lactam

Application

Cefaclor is used to study urinary tract, intra-abdominal, and Haemophilus influenzae infections [1][2][3]. It is used to study the mechanism of human renal organic anion and peptide transporters such as hOAT1, hPEPT1, and hPEPT2 and to study the effects of inhibition of penicillin-binding proteins on bacterial cell wall mucopeptide synthesis [4].

Cefaclor has been used in the heterologous expression of AaOr7 and AaOr8 in Xenopus laevis oocytes. It has also been used in cultures of isolated trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons.

Biochem/physiol Actions

Cefaclor is a second generation cephalosporin with broad spectrum activity against Gram-negative and Gram-positive bacteria. It binds to penicillin-binding proteins and thereby inhibits the cell wall synthesis causing cell death.[1]

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Slightly soluble in water, practically insoluble in methanol, chloroform and benzene.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves