This product is the full-length, unmodified, native protein from human serum. Complement C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da.
C2787
Complement C7 from human serum
≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein
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0.1 MG
1230,00 zł
1230,00 zł
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Informacje o tej pozycji
Form:
solution
Assay:
≥85% (SDS-PAGE)
Biological source:
human serum
Przejdź do
Pomoc techniczna
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Pozwól nam pomócbiological source
human serum
Quality Level
assay
≥85% (SDS-PAGE)
form
solution
specific activity
≥150,000 C7H50 units/mg protein
concentration
1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
technique(s)
activity assay: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... C7(730)
1 of 4
Ta pozycja | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) immunoelectrophoresis: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| assay ≥85% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay ≥85% (SDS-GE) | assay - |
| biological source human serum | biological source human | biological source human | biological source human |
| concentration 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration - | concentration - |
| form solution | form solution | form solution | form liquid |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Biochem/physiol Actions
The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
Analysis Note
Functionally active by a sensitive hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
A F Esser
Toxicology, 87(1-3), 229-247 (1994-02-28)
The membrane attack complex of complement is formed by the molecular fusion of the five terminal complement proteins, C5, C6, C7, C8, and C9. While the assembly process on a target membrane and its modulation by restriction factors present on
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C2787-.1MG | 04061833484623 |
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I would like to know if the product is a full sequence protein (92.4 kDa, 843 AA)?
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