C8195
Complement C4 from human serum
≥300,000 C4H50 units/mg protein
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About This Item
Polecane produkty
pochodzenie biologiczne
human serum
Poziom jakości
Postać
solution
aktywność właściwa
≥300,000 C4H50 units/mg protein
metody
activity assay: suitable
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... C4A(720)
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Opis ogólny
Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.
Zastosowanie
Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.
Działania biochem./fizjol.
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.
There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Postać fizyczna
Supplied as a solution in PBS, pH 7.2
Inne uwagi
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Oświadczenie o zrzeczeniu się odpowiedzialności
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Klienci oglądali również te produkty
Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4
Blanchong CA, et al.
International Immunopharmacology, 1(3), 365-392 (2001)
Yan Yang et al.
Current directions in autoimmunity, 7, 98-132 (2004-01-15)
It was observed about 50 years ago that low serum complement activity or low protein concentrations of complement C4 concurred with disease activities of systemic lupus erythematosus (SLE). Complete deficiencies of complement components C4A and C4B, albeit rare in human
Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney
Bay JT, et al.
Kidney International, 84(3), 562-569 (2013)
Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50.
Yang Y., et al.
Veterinary Immunology and Immunopathology (2011)
Schizophrenia risk from complex variation of complement component 4
Sekar A, et al.
Nature, 530(7589), 177-177 (2016)
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