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B8562
BD 1047 dihydrobromide
≥95% (HPLC)
Synonim(y):
BD 1047 dihydrobromide
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 499,00 zł | |
| 25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1950,00 zł 1657,50 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C13H20Cl2N2 · 2 HBr
Numer CAS:
Masa cząsteczkowa:
437.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
499,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócQuality Level
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >5 mg/mL
storage temp.
2-8°C
SMILES string
Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1
InChI
1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
InChI key
WOALTFHGLDVJHK-UHFFFAOYSA-N
Application
BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.[1]
BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.
Biochem/physiol Actions
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity.
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.
In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.[2]
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Ta pozycja | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
| solubility H2O: >5 mg/mL | solubility H2O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL | solubility H2O: 20 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
![cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide ≥98% (HPLC), solid](/deepweb/assets/sigmaaldrich/product/structures/255/210/7ae0c9f3-835e-4c95-aa84-bb7695fe11ac/640/7ae0c9f3-835e-4c95-aa84-bb7695fe11ac.png)
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Tao Bai et al.
Journal of cellular and molecular medicine, 23(11), 7349-7359 (2019-09-12)
Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is a strong inducer of ferroptosis but not of apoptosis. However, the mechanism of sorafenib-induced
Omar Vélez López et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 14(2), 226-240 (2018-10-12)
Pathogenesis of HIV-associated neurocognitive disorders (HAND) is mediated through the infiltration of perivascular macrophages into the brain with the secretion of viral, neurotoxic and inflammatory proteins. One of these proteins is cathepsin B (CATB), a lysosomal cysteine protease that induces
Susmita Sil et al.
Molecular neurobiology, 56(5), 3576-3590 (2018-08-29)
Cocaine, a known psychostimulant, results in oxidative stress and inflammation. Recent studies from our group have shown that cocaine induces inflammation in glial cells. Our current study was aimed at investigating whether cocaine exposure could also induce inflammation in non-glial
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| B8562-5MG | 04061833228555 |
| B8562-25MG | 04061833228548 |