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Key Documents

A6106

Sigma-Aldrich

Aprotinin

BioUltra, 3-8 TIU/mg solid, powder, ≥98% (SDS-PAGE), suitable for inhibition assay

Synonim(y):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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About This Item

Wzór empiryczny (zapis Hilla):
C284H432N84O79S7
Numer CAS:
9087-70-1
Masa cząsteczkowa:
6511.44
Numer WE:
232-994-9
Numer MDL:
MFCD00130541
Kod UNSPSC:
12352204
NACRES:
NA.77

product name

Aprotinin from bovine lung, BioUltra, 3-8 TIU/mg solid, ≥98% (SDS-PAGE)

pochodzenie biologiczne

bovine lung

Poziom jakości

300

linia produktu

BioUltra

Próba

≥98% (SDS-PAGE)

Postać

powder

aktywność właściwa

3-8 TIU/mg solid

masa cząsteczkowa

~6,500

metody

inhibition assay: suitable

rozpuszczalność

H2O: 5 mg/mL, clear to very slightly hazy

numer dostępu UniProt

P00974

temp. przechowywania

2-8°C

Klucz InChI

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

informacje o genach

cow ... PTI(404172)

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Zastosowanie

Aprotinin is largely used as an inhibitor of trypsin.

Działania biochem./fizjol.

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Definicja jednostki

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.
One trypsin inhibitor unit (TIU) will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmole of N-α-benzoyl-DL-arginine p-nitroanilide (BAPNA) per min at pH 7.8 at 25 °C.

Uwaga dotycząca przygotowania

A further purification of A1153 to yield a product with slightly higher activity and purity
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Cecilia B Levandowski et al.
PLoS biology, 19(8), e3001364-e3001364 (2021-08-06)
The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity. We circumvented this issue with a well-tested strategy that expressed
Luciana Mateus Gonçalves et al.
Frontiers in endocrinology, 11, 602519-602519 (2021-02-02)
Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine cells with their vascular system. Islets receive blood through feeding arteriole(s) that branch into capillaries
Luming Wan et al.
Nature metabolism, 4(1), 29-43 (2022-01-08)
Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. However, the molecular mechanisms for how SARS-CoV-2 infection alters glycometabolic control are incompletely understood. Here, we connect the
Benjamin J Patty et al.
Nature protocols, 16(5), 2633-2666 (2021-04-30)
Determining chromatin-associated protein localization across the genome has provided insight into the functions of DNA-binding proteins and their connections to disease. However, established protocols requiring large quantities of cell or tissue samples currently limit applications for clinical and biomedical research
Verena van der Heide et al.
Cell reports, 38(11), 110508-110508 (2022-03-06)
Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and precise risk assessment is hampered by, at times, conflicting evidence.
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Produkty

Aprotinin

While aprotinin and bovine pancreatic trypsin inhibitor (BPTI) are the same protein sequence, the term aprotinin is typically used when describing the protein derived from bovine lung.

Protokoły

Enzymatic Assay of Aprotinin

Objective: To standardize a procedure for the enzymatic assay of Aprotinin.

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