A2478

APHA Compound 8

solid, ≥98% (HPLC)

• Synonim(y): 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
• Wzór empiryczny (zapis Hilla): C₁₆H₁₆N₂O₃
• Numer CAS: 676599-90-9
• Masa cząsteczkowa: 284.31
• MDL number: MFCD29074969
• UNSPSC Code: 12352202
• PubChem Substance ID: 329770785
• NACRES: NA.77

Właściwości

• Nazwa produktu: APHA Compound 8, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
• InChI: 1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
• InChI key: UFQOXIMRSMFQRI-BQYQJAHWSA-N

Opis

Biochem/physiol Actions

HDAC (histone deacetylase) inhibitor.

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H317,H318
• pcodes: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves