04573

Thiamine hydrochloride

tested according to Ph. Eur.

• Synonim(y): Thiamio hydrochloridum, Aneurine hydrochloride, Vitamin B₁ hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₇ClN₄OS · HCl
• Numer CAS: 67-03-8
• Masa cząsteczkowa: 337.27
• NACRES: NA.26
• PubChem Substance ID: 329747946
• eCl@ss: 34058006
• UNSPSC Code: 12352209
• EC Number: 200-641-8
• MDL number: MFCD00012780
• Beilstein/REAXYS Number: 3851771

Właściwości

• biological source: synthetic
• Quality Level: 200
• agency: tested according to Ph. Eur.
• assay: 98.5-101.0% anhydrous basis
• form: solid
• mp: 250 °C (dec.) (lit.)
• solubility: alcohol: soluble 1 gm in 100 ml (95%), alcohol: soluble 1 gm in 315 ml (Absolute), glycerol: soluble 1 gm in 18 ml, water: soluble 1 g/mL, benzene: insoluble, chloroform: insoluble, diethyl ether: insoluble, hexane: insoluble, methanol: very soluble, propylene glycol: soluble
• storage temp.: 2-8°C
• SMILES string: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• InChI key: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Opis

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus.[1] It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.[2]

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon.[3] Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.[4]

Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B₁). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)