AG723-M

C-Reactive Protein

• Synonim(y): CRP
• UNSPSC Code: 12352202
• NACRES: NA.41
• eCl@ss: 32160405
• Form: liquid
• Assay: >98% (SDS-PAGE)
• Biological source: human

Właściwości

• biological source: human
• Quality Segment: 100, 300
• assay: >98% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Chemicon^®
• NCBI accession no.: NM_000567.2
• UniProt accession no.: P02741

Opis

General description

C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.[1]

Application

C-reactive protein (CRP) has been used:

• as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)[2]
• to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation[3]
• to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response[4]

Biochem/physiol Actions

C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.[4]

Physical form

Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl₂

Preparation Note

Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.

Analysis Note

No precipitin bands when tested at 2 mg/mL against anti-whole human serum.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable