567630

Sodium Salicylate

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

• Synonim(y): Sodium Salicylate, Salicylic Acid, Na, NaSal
• Wzór empiryczny (zapis Hilla): C₇H₅O₃ · Na
• Numer CAS: 54-21-7
• Masa cząsteczkowa: 160.10
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00002440
• Assay: ≥98% (titration)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Quality Segment: 100
• description: Merck USA index - 14, 8332
• assay: ≥98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: off-white
• solubility: water: 50 mg/mL, ethanol: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [Na+].[O-]C(=O)c1c(cccc1)O
• InChI: 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
• InChI key: ABBQHOQBGMUPJH-UHFFFAOYSA-M

Opis

General description

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H319,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: 208.9 °F - Pensky-Martens closed cup
• flash_point_c: 98.3 °C - Pensky-Martens closed cup