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553511

Rac1 Inhibitor II

The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonim(y):

Rac1 Inhibitor II, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

479,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C20H21N3O5S
Numer CAS:
1090893-12-1
Masa cząsteczkowa:
415.46
MDL number:
MFCD00001079
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥93% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

479,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

​
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Quality Level

100

assay

≥93% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). Also available in InSolution format (Cat. No. 553512).

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
553502553512238811
Rac1 Inhibitor II The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

553511

Rac1 Inhibitor II

Rac1 Inhibitor Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC50 ~50 µM).

Sigma-Aldrich

553502

Rac1 Inhibitor

Rac1 Inhibitor II, Z62954982 InSolution, ≥93%

Sigma-Aldrich

553512

Rac1 Inhibitor II, Z62954982

Cdk9 Inhibitor II The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

238811

Cdk9 Inhibitor II

assay

≥93% (HPLC)

assay

≥93% (HPLC)

assay

≥93% (HPLC)

assay

≥95% (HPLC)

form

solid

form

lyophilized

form

liquid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 100 mg/mL

solubility

water: 5 mg/mL

solubility

-

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Keita Hanada et al.
Cancer letters, 522, 129-141 (2021-09-21)
Mutations of KRAS gene are found in various types of cancer, including colorectal cancer (CRC). Despite intense efforts, no pharmacological approaches are expected to be effective against KRAS-mutant cancers. Macropinocytosis is an evolutionarily conserved actin-dependent endocytic process that internalizes extracellular
Yueyang Wang et al.
eLife, 12 (2023-09-19)
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show that in mouse embryonic fibroblasts, MFN2 suppresses
Wenqing Zhou et al.
Journal of cell science, 133(17) (2020-08-14)
Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis in vivo Mfn2-deficient neutrophils are released from the

Numer pozycji handlu globalnego

SKUNUMER GTIN
553511-10MG04055977193701

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