This product is a 5 mM (500 µg/109 µl) solution of Rapamycin in DMSO. The 1 mg pack size should have approximately 218 µl.
553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Synonim(y):
InSolution Rapamycin, mTOR Inhibitor I
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1010,00 zł | |
| 500 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1260,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C51H79NO13
Masa cząsteczkowa:
914.17
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solution
Quality level:
Storage condition:
desiccated (hygroscopic), protect from light
1010,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Quality Level
assay
≥95% (HPLC)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Packaging
Packaged under inert gas
Physical form
2.5 mg/mL solution in DMSO (2.74 mM)
Preparation Note
Following initial use, aliquot and freeze (-20°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Ta pozycja | |||
|---|---|---|---|
| form solution | form powder | form liquid | form liquid |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. −20°C | storage temp. −20°C | storage temp. −70°C | storage temp. −20°C |
| storage condition desiccated (hygroscopic), protect from light | storage condition OK to freeze | storage condition OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light | storage condition OK to freeze, desiccated (hygroscopic), protect from light |
Klasa składowania
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Rachel M Wise et al.
Cells, 9(10) (2020-10-04)
Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived stem cells (BMSCs) elevated secretion of prostaglandin E2, a pleiotropic molecule
Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis.
Esmaeilian, et al.
Cell Death & Disease, 14, 342-342 (2023)
Tara Alpert et al.
Cell reports, 33(4), 108324-108324 (2020-10-29)
Nascent RNA sequencing has revealed that pre-mRNA splicing can occur shortly after introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional splicing profiles suggest regulation by cis- and/or trans-acting factors. Here, we use single-molecule intron tracking (SMIT)
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 553211-500UG | 04055977193558 |
| 553211-1MG | 04055977193541 |
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