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521233

PDGFR Tyrosine Kinase Inhibitor IV

Synonim(y):

PDGFR Tyrosine Kinase Inhibitor IV, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409

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Gabaryty przesyłkiSKUDostępnośćCena netto
1 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

1080,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C18H16FN3O2
Numer CAS:
627518-40-5
Masa cząsteczkowa:
325.34
MDL number:
MFCD11045292
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

1080,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

​
Pomoc techniczna
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Pozwól nam pomóc

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mg/mL, methanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Fc1cc(ccc1)Nc2[nH]nc3c2Cc4c3cc(c(c4)OC)OC

InChI

1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)

InChI key

ZDNURMVOKAERHZ-UHFFFAOYSA-N

General description

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50<33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk′s-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PDGFR Tyrosine Kinase
Product competes with ATP.
Reversible: yes
Target IC50: 4.2 nM and 45 nM for -β and -α form of PDGFR, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ho, C.Y., et al. 2005. J. Med. Chem.48, 8163.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)
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521234521231676481
PDGFR Tyrosine Kinase Inhibitor IV

Sigma-Aldrich

521233

PDGFR Tyrosine Kinase Inhibitor IV

PDGFR Tyrosine Kinase Inhibitor V The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &amp; Dephosphorylation applications.

Sigma-Aldrich

521234

PDGFR Tyrosine Kinase Inhibitor V

PDGFR Tyrosine Kinase Inhibitor II The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &amp; Dephosphorylation applications.

Sigma-Aldrich

521231

PDGFR Tyrosine Kinase Inhibitor II

VEGFR Tyrosine Kinase Inhibitor II The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &amp; Dephosphorylation applications.

Sigma-Aldrich

676481

VEGFR Tyrosine Kinase Inhibitor II

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, methanol: 5 mg/mL

solubility

DMSO: 25 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL, methanol: soluble

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

Certyfikaty analizy (CoA)

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Numer pozycji handlu globalnego

SKUNUMER GTIN
521233-1MG04055977271379

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