This product is tested for solubility in water at 10 mg/mL. Following reconstitution, aliquoting and freezing at -20°C is recommended. Stock solutions remain stable for up to 1 month at -20°C.
420318
Kainic Acid
≥98% (HPLC), solid, amino acid receptor agonist, Calbiochem®
Synonim(y):
Kainic Acid, 2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 1470,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C10H15NO4
Numer CAS:
Masa cząsteczkowa:
213.23
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.77
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Kainic Acid, An excitatory amino acid receptor agonist selective for the kainate receptor subtype (Ki = 21 nM for ³H-kainate binding in rat striatum).
Quality Level
description
Merck USA index - 14, 5276
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
dilute base: 10 mg/mL, water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[N+H2]1[C@@H]([C@H]([C@H](C1)C(=C)C)CC(=O)O)C(=O)[O-]
InChI
1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChI key
VLSMHEGGTFMBBZ-OOZYFLPDSA-N
General description
An excitatory amino acid receptor agonist selective for the kainate receptor subtype (Ki = 21 nM for 3H-kainate binding in rat striatum). Also activates AMPA receptors.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Kainate receptor subtype
Kainate receptor subtype
Product does not compete with ATP.
Reversible: no
Target Ki: 21 nM for 3H-kainate binding in rat striatum
Other Notes
Niu, L., et al. 1996. Biochemistry35, 2030.
Watkins, J.C. and Evans, R.H. 1981. Annu. Rev. Pharmacol. Toxicol. 21, 165.
Watkins, J.C. and Evans, R.H. 1981. Annu. Rev. Pharmacol. Toxicol. 21, 165.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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Ta pozycja | |||
|---|---|---|---|
| form solid | form powder | form powder | form solid |
| assay ≥98% (HPLC) | assay ≥99% (TLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility dilute base: 10 mg/mL, water: 10 mg/mL | solubility H2O: soluble | solubility H2O: >10 mg/mL | solubility DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certyfikaty analizy (CoA)
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Powiązane treści
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 420318-10MG | 04055977211016 |
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