407950

Ionomycin free acid

from Streptomyces conglobatus, ≥90% (HPLC), waxy solid, Ca2+ mobile ion carrier, Calbiochem^®

• Synonim(y): Ionomycin, Free Acid, Streptomyces conglobatus
• Wzór empiryczny (zapis Hilla): C₄₁H₇₂O₉
• Numer CAS: 56092-81-0
• Masa cząsteczkowa: 709.00
• Numer MDL: MFCD06798385
• Kod UNSPSC: 12352106
• NACRES: NA.77

Właściwości

• Nazwa produktu: Ionomycin, Free Acid, Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca²⁺.
• Poziom jakości: 100
• opis: RTECS - NO0600000
• Próba: ≥90% (HPLC)
• Formularz: waxy solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• rozpuszczalność: DMSO: 10 mg/mL; methanol: 10 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
• Klucz InChI: PGHMRUGBZOYCAA-OJFQOPKISA-N

Opis

Opis ogólny

Absorption max. (280 nm, MeOH): 18,600 M^-1cm^-1.

Highly specific for divalent cations (Ca²⁺ > Mg²⁺ >> Sr²⁺ = Ba²⁺). More effective than antibiotic A23187 as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes and measurement of cytoplasmic free Ca²⁺. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G₁ interval of mature Burkitt lymphoma cell lines.

Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes and measurement of cytoplasmic free Ca²⁺. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G₁ phase in mature Burkitt lymphoma cell lines.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Mobile ion carrier for Ca2+

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Harmful (C)

Rekonstytucja

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.

Inne uwagi

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem.253, 5892.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3