368056

Granzyme B Inhibitor IV

≥97% (HPLC), granzyme B inhibitor, solid

• Synonim(y): Granzyme B Inhibitor IV, Ac-IEPD-CHO, Caspase-8 inhibitor III
• Wzór empiryczny (zapis Hilla): C₂₂H₃₄N₄O₉
• Masa cząsteczkowa: 498.53
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: Granzyme B Inhibitor IV, The Granzyme B Inhibitor IV controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

A reversible inhibitor of Granzyme B that also inhibits caspase-8. Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.

A reversible inhibitor of granzyme B and caspase-8.

Biochem/physiol Actions

Cell permeable: no

Primary Target
granzyme B

Product does not compete with ATP.

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Ile-Glu-Pro-Asp-CHO

Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem.272, 17907.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable