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352010

Glutaminase Inhibitor, Compound 968

Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.

Synonim(y):

Glutaminase Inhibitor, Compound 968, GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

924,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C27H27BrN2O
Numer CAS:
311795-38-7
Masa cząsteczkowa:
475.42
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00606231
Assay:
≥99% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

924,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

​
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Quality Level

100

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CC(C)(C)C1)C2=C1C3=C(NC2C4=CC(Br)=C(C=C4)N(C)C)C=CC5=C3C=CC=C5

InChI key

NVFRRJQWRZFDLM-UHFFFAOYSA-N

General description

A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days). Also available as a 10 mM solution in DMSO (Cat. No. 5.06073).

Packaging

Packaged under inert gas

Other Notes

Wang, J.B., et al. 2010. Cancer Cell18, 207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
SML13275.06073361548
Glutaminase Inhibitor, Compound 968 Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.

Sigma-Aldrich

352010

Glutaminase Inhibitor, Compound 968

Glutaminase Inhibitor 968 ≥98% (HPLC)

Sigma-Aldrich

SML1327

Glutaminase Inhibitor 968

Glutaminase Inhibitor, Compound 968 InSolution, ≥99%, A cell-permeable benzophenanthridinone compound

Sigma-Aldrich

5.06073

Glutaminase Inhibitor, Compound 968

GSK-3β Inhibitor VII The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361548

GSK-3β Inhibitor VII

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

liquid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 5 mg/mL

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Ying Zhang et al.
Oxidative medicine and cellular longevity, 2023, 9808100-9808100 (2023-01-20)
Ferroptosis, a newly identified form of cell death, plays critical roles in the development and chemoresistance of lung cancer. Tripartite motif 6 (TRIM6) acts as an E3-ubiquitin ligase and can promote the progression of human colorectal cancer. The present study
Hamed Alborzinia et al.
Nature cancer, 3(4), 471-485 (2022-04-29)
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces massive lipid peroxidation on
Katharina Koch et al.
Cell death discovery, 6, 20-20 (2020-04-28)
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy. Several tumors excessively metabolize glutamine to generate precursors for
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SKUNUMER GTIN
352010-10MG04055977193237

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