344101

FSB

A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

• Synonim(y): FSB, (E,E)-1-Fluoro-2,5- bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
• Wzór empiryczny (zapis Hilla): C₂₄H₁₇FO₆
• Numer CAS: 760988-03-2
• Masa cząsteczkowa: 420.39
• MDL number: MFCD28902305
• UNSPSC Code: 41105331
• NACRES: NA.25
• Assay: ≥95% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Fc1c(ccc(c1)\C=C\c3cc(c(cc3)O)C(=O)O)\C=C\c2cc(c(cc2)O)C(=O)O
• InChI key: DZXZHGCGNRRJEG-WMWQKROPSA-N

Opis

General description

A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.

This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Amyloidophilic fluorescent probe

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable