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324693

Millipore

Emetine dihydrochloride

≥98% (HPLC), solid, protein synthesis blocker, Calbiochem®

Synonim(y):

Emetine, Dihydrochloride, 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl

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About This Item

Wzór empiryczny (zapis Hilla):
C29H40N2O4 · 2HCl
Numer CAS:
316-42-7
Masa cząsteczkowa:
553.56
Numer MDL:
MFCD00242944
Kod UNSPSC:
41116107
NACRES:
NA.77

product name

Emetine, Dihydrochloride, Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.

Poziom jakości

100

Próba

≥98% (HPLC)

Postać

solid

producent / nazwa handlowa

Calbiochem®

warunki przechowywania

OK to freeze
desiccated (hygroscopic)
protect from light

kolor

white to off-white
 white

rozpuszczalność

water: 20 mg/mL
ethanol: soluble

Warunki transportu

ambient

temp. przechowywania

2-8°C

InChI

1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

Klucz InChI

JROGBPMEKVAPEH-GXGBFOEMSA-N

Opis ogólny

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.

Działania biochem./fizjol.

Cell permeable: no
Primary Target
Movement of ribosomes along the mRNA
Product does not compete with ATP.
Reversible: no
Target IC50: ≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity

Ostrzeżenie

Toxicity: Highly Toxic (H)

Rekonstytucja

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kong, H.S., et al. 2010. Mol. Pharmacol.in press.
Khan, M.A. 1995. Prog. Neurobiol.46, 541.
Kokuho, T., et al. 1995. Immunobiology193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett.93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun.59, 2567.
Landis, R.C., et al. 1991. J. Immunol.146, 128.
Schweighoffer, T., et al. 1991. Histochemistry96, 93.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300,H315,H319

Klasyfikacja zagrożeń

Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Mina O Seedhom et al.
eLife, 12 (2024-03-21)
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ribosomes in resting lymphocytes in vitro and in vivo
Kosuke Tanaka et al.
Cancer cell, 39(9), 1245-1261 (2021-08-14)
The clinical success of EGFR inhibitors in EGFR-mutant lung cancer is limited by the eventual development of acquired resistance. We hypothesize that enhancing apoptosis through combination therapies can eradicate cancer cells and reduce the emergence of drug-tolerant persisters. Through high-throughput
June Bryan de la Peña et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(37), 7712-7726 (2021-07-31)
Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite the pervasive role of translational regulation in nociception, the contribution of activity-dependent protein synthesis
Julie Bergalet et al.
Cell reports, 30(10), 3339-3352 (2020-03-12)
Overlapping genes are prevalent in most genomes, but the extent to which this organization influences regulatory events operating at the post-transcriptional level remains unclear. Studying the cen and ik2 genes of Drosophila melanogaster, which are convergently transcribed as cis-natural antisense
Braulio Martinez De La Cruz et al.
Molecular psychiatry, 26(12), 7141-7153 (2021-10-20)
Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated

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