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204878

Dopełniacz C1r, ludzki, aktywowany, forma dwułańcuchowa

Name: Dopełniacz C1r, ludzki, aktywowany, forma dwułańcuchowa
Brand: MM

Complement C1r, Human, Activated, Two-Chain Form, CAS 80295-34-7, is a native, activated, C1r complement component.

Synonim(y):

Complement C1r, Human, Activated, Two-Chain Form

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Informacje o tej pozycji

Numer CAS:

80295-34-7

MDL number:

MFCD00270206

NACRES:

NA.25

UNSPSC Code:

12352202

Form:

liquid

Assay:

≥90% (SDS-PAGE)

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Właściwości

Quality Segment

100

assay

≥90% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH, trace

shipped in

wet ice

storage temp.

−70°C

Opis

General description

Native, human, activated, C1r complement component. Generally, non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to the classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35,000 peptide contains C1r enzymatic active site. Activated C1r continues activation via the classical pathway by cleaving, and thus activating C1s.

Biochem/physiol Actions

≥80% of C1r will bind with excess C1-INH

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	204873	C1740	204860
Sigma-Aldrich 204878 Complement C1r, Human, Activated, Two-Chain Form	Sigma-Aldrich 204873 Complement C1, Human	Sigma-Aldrich C1740 Complement component C1q from human serum	Sigma-Aldrich 204860 Complement C3b, Human
assay ≥90% (SDS-PAGE)	assay -	assay ≥95% (SDS-PAGE)	assay ≥90% (SDS-PAGE)
form liquid	form liquid	form liquid	form liquid
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C
shipped in wet ice	shipped in wet ice	shipped in dry ice	shipped in wet ice
impurities IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH, trace	impurities -	impurities -	impurities IgG, IgA, IgM, C5, Factor H, or Factor I, trace
storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition -	storage condition OK to freeze, avoid repeated freeze/thaw cycles

Klasa składowania

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c