203701

bpV(HOpic)

A potent phosphotyrosine phosphatase inhibitor.

• Synonim(y): Bisperokso(5-hydroksypirydyno-2-karboksylo)oksowanadan dipotasu (V), inhibitor PTEN III, inhibitor PTP XV
• Wzór liniowy: K₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥70% (⁵¹V-NMR)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥70% (⁵¹V-NMR)
• form: solid
• potency: 14 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: water: 4 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC₅₀ = 14 nM).

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: no

Primary Target
PTEN

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable