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Informacje o tej pozycji

UNSPSC Code:
41116012
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
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form

liquid

Quality Segment

100

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

shipped in

dry ice

General description

Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.[1]

Application

Peroxynitrite has been used to induce pericyte contraction in mouse brains.[1] It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.[2]

Biochem/physiol Actions

Peroxynitrite (ONOO−) exhibits bactericidal activity.[3] It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.[1]

Physical form

0.3M NaOH

Analysis Note

Routinely evaluated by treating non-stimulated A431 cells.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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516620SCT035N0409
Peroxynitrite

Sigma-Aldrich

20-107

Peroxynitrite

Peroxynitrite Synthesized from isoamyl nitrite and hydrogen peroxide.

Sigma-Aldrich

516620

Peroxynitrite

BioTracker 515 Green ONOO- Dye Live cell imaging dye for peroxynitrite (ONOO-) used to detect reactive oxygen species (ROS) generated from the interaction of nitric oxide (NO) and superoxide (O).

Sigma-Aldrich

SCT035

BioTracker 515 Green ONOO- Dye

Anti-Nitrotyrosine antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

N0409

Anti-Nitrotyrosine antibody produced in rabbit

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

200

form

liquid

form

liquid

form

-

form

buffered aqueous solution

technique(s)

western blot: suitable

technique(s)

-

technique(s)

cell based assay: suitable

technique(s)

immunohistochemistry (frozen sections): 1:1000 using methacarn-fixed, frozen sections of human Alzheimer′s Disease brain, indirect ELISA: 1:1,000 using nitrated-BSA, indirect immunofluorescence: 1:1,000 using A549 cells metabolically labeled with 3-nitrotyrosine, microarray: suitable, western blot: 1:1,000 using nitrated-BSA

shipped in

dry ice

shipped in

wet ice

shipped in

ambient

shipped in

dry ice

manufacturer/tradename

Upstate®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

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pictograms

Corrosion
GHS05

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Klasa składowania

12 - Non Combustible Liquids

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
A Patel et al.
Journal of endocrinological investigation, 25(8), 675-683 (2002-09-21)
Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested
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SKUNUMER GTIN
20-10704053252671265
Z114014-144EA04061832325828
Z114014-12EA04061832325811

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