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Key Documents

19-148

Sigma-Aldrich

Bafilomycin A1

Synonim(y):

Bafilomycin A

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About This Item

Kod UNSPSC:
12352106
eCl@ss:
32160405
NACRES:
NA.41

opis

Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.

Poziom jakości

producent / nazwa handlowa

Upstate®

metody

activity assay: suitable (kinase)

temp. przechowywania

−20°C

Zastosowanie

Bafilomycin A1 has been used:
  • as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
  • to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
  • to block autophagy in mouse embryonic fibroblasts

Działania biochem./fizjol.

Inhibitor Type: Kinase

Postać fizyczna

C35H58O9

Przechowywanie i stabilność

3 years at -20°C

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Wenchang Xiao et al.
Signal transduction and targeted therapy, 6(1), 152-152 (2021-04-17)
Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation. Although the processes of autophagosome biogenesis have been well illuminated, the mechanism
Seongju Lee et al.
International journal of molecular sciences, 21(21) (2020-11-01)
Keloid is a representative chronic fibroproliferative condition that occurs after tissue injury. Emerging evidence showed that activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in the pro-inflammatory response in injured tissues. However, the role of
Seongju Lee et al.
Science signaling, 13(613) (2020-01-09)
Mutations in WASHC5 (also known as KIAA0196) cause autosomal dominant hereditary spastic paraplegia (HSP) type SPG8. WASHC5, commonly called strumpellin, is a core component of the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex that activates actin nucleation at endosomes.
Jianzhong Li et al.
Frontiers in cell and developmental biology, 8, 576988-576988 (2020-12-15)
Bixin, a natural carotenoid extracted from the seeds of Bixa orellana, has antioxidant and anti-inflammation effects. However, the pharmacological effects and underlying mechanisms of bixin in kidney interstitial fibrosis remain unknown. Partial epithelial-to-mesenchymal transition (EMT) of tubular cells has been
Asli E Dogan et al.
The Journal of biological chemistry, 298(7), 102050-102050 (2022-05-23)
The double-stranded RNA-dependent protein kinase activating protein (PACT), an RNA-binding protein that is part of the RNA-induced silencing complex, plays a key role in miR-mediated translational repression. Previous studies showed that PACT regulates the expression of various miRs, selects the

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