137141

Spermine tetrahydrochloride

EMPROVE^® EVOLVE

• Synonim(y): N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Wzór empiryczny (zapis Hilla): C₁₀H₂₆N₄ · 4HCl
• Numer CAS: 306-67-2
• Masa cząsteczkowa: 348.18
• UNSPSC Code: 12352116
• Beilstein/REAXYS Number: 3911771
• MDL number: MFCD00012914

Właściwości

• biological source: synthetic
• Quality Level: 400
• agency: non-compendial
• form: powder
• concentration: 99.0-101.0 % (w/w) (T)
• impurities: ≤5000 mg/kg ethanol (HS-GC), ≤890 mg/kg toluene (HS-GC)
• mp: 310-311 °C (dec.) (lit.)
• cation traces: Al: ≤25 mg/kg, Cr: ≤2.5 mg/kg, Cu: ≤25 mg/kg, Fe: ≤130 mg/kg, Ni: ≤2.5 mg/kg, Zn: ≤130 mg/kg
• suitability: corresponds for identity (¹H-NMR)
• application(s): pharma/biopharma processes
• storage temp.: 15-25°C
• SMILES string: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChI key: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Opis

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315 - H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable