1.06757

Methyl 4-hydroxybenzoate

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, NF

• Synonim(y): Methyl 4-hydroxybenzoate, Methylparaben, 4-Hydroxybenzoic acid methyl ester
• Wzór liniowy: 4-(OH)C₆H₄(COOCH₃)
• Numer CAS: 99-76-3
• Masa cząsteczkowa: 152.15
• UNSPSC Code: 12352108
• EC Index Number: 202-785-7
• MDL number: MFCD00002352

Właściwości

• Quality Segment: 500
• agency: BP, ChP, JP, NF, Ph. Eur.
• vapor pressure: 0.000005 hPa ( 20 °C)
• product line: EMPROVE^® EXPERT
• assay: 99.0-100.5% (HPLC), 99.0-102.0% (acidimetric)
• form: solid
• autoignition temp.: >600 °C
• technique(s): API processing | cocrystal formation: suitable
• pH: 5.8 (20 °C in H₂O, saturated solution)
• mp: 125 °C
• solubility: 1.88 g/L
• density: 1.38 g/cm³ at 20 °C
• application(s): liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 15-25°C
• SMILES string: O(C)C(=O)c1ccc(cc1)O
• InChI: 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
• InChI key: LXCFILQKKLGQFO-UHFFFAOYSA-N

Opis

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS09
• hcodes: H411
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: 334.4 °F
• flash_point_c: 168 °C