1.01900

Dimethyl sulfoxide

for headspace gas chromatography SupraSolv^®

• Synonim(y): Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO, DMSO
• Wzór liniowy: (CH₃)₂SO
• Numer CAS: 67-68-5
• Masa cząsteczkowa: 78.13
• UNSPSC Code: 12191502
• NACRES: NA.03
• EC Index Number: 200-664-3
• MDL number: MFCD00002089
• Beilstein/REAXYS Number: 506008
• Assay: ≥99.8% (GC)
• Technique(s): GC-HS: suitable
• Bp: 189 °C (lit.)
• Vapor pressure: 0.42 mmHg ( 20 °C)

Właściwości

• Quality Level: 100
• agency: according to Ph. Eur., according to USP
• vapor density: 2.7 (vs air)
• vapor pressure: 0.42 mmHg ( 20 °C)
• product line: SupraSolv^®
• assay: ≥99.8% (GC)
• form: liquid
• autoignition temp.: 573 °F
• potency: 28300 mg/kg LD₅₀, oral (Rat), 40000 mg/kg LD₅₀, skin (Rat)
• expl. lim.: 42 %, 63 °F
• technique(s): GC-HS: suitable
• impurities: ≤0.05% Water
• evapn. residue: ≤3.0 mg/L
• color: APHA: ≤10
• refractive index: n20/D 1.479 (lit.)
• kinematic viscosity: 2.14 cSt
• bp: 189 °C (lit.)
• mp: 16-19 °C (lit.)
• transition temp: flash point 87 °C
• density: 1.10 g/mL (lit.)
• storage temp.: 2-30°C
• SMILES string: CS(C)=O
• InChI: 1S/C2H6OS/c1-4(2)3/h1-2H3
• InChI key: IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Opis

General description

SupraSolv solvents for headspace gas chromatography are developed particularly for the analysis of residual
solvents in drug substances, excipients and drug products according to ICH, Ph Eur and USP - SupraSolv headspace solvents are tested for all
residual solvents defined by the ICH.

Application

DMSO can be used as an effective solvent for dissolving a wide range of polar and non-polar compounds for sample preparation in HS-GC. Its high polarity allows for the extraction of volatile organic compounds (VOCs) from complex matrices, such as biological samples or environmental matrices. DMSO also enhances the volatility of certain compounds, facilitating their detection in HS-GC. By modifying the physical properties of the analytes, DMSO helps in achieving better separation and sensitivity during the chromatographic analysis.

Features and Benefits

Saturation Concentration in Air: 8.0 g/m3 (20 °C)

Analysis Note

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 3.0 mg/l
Water: ≤ 0.05 %
Color: ≤ 10 Hazen
GC/HS (Every residual solvent of class 1acc. ICH): ≤ 1 µg/g
GC/HS (Every residual solvent of class 2acc. ICH): ≤ 10 µg/g
GC/HS (Every residual solvent of class 3acc. ICH): ≤ 50 µg/g
Suitable as solvent for the analysis of residual solvents of ICH classes 1,2 and 3 according to Ph Eur and USP.
Formic acid, acetic acid, dimethylacetamide and cumene are not detected.

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup