03-0177-00

Zestaw do wysokoczułego testu immunologicznego ^® z ludzkim heterodimerem IL-17A/F

Used for ultrasensitive quantification of Human IL-17A/F Heterodimer in human serum and plasma

• Synonim(y): Ultraczuły test immunologiczny IL-17A/F, Zestaw do liczenia pojedynczych cząsteczek IL-17A/F
• NACRES: NA.84
• UNSPSC Code: 12161503
• Species reactivity: human
• Technique(s): single molecule counting: suitable
• Usage: kit sufficient for 96 wells
• Compatibility: for use with TM="FemtoQuest"] and SMCxPRO^® instruments

Właściwości

• Nazwa produktu: Zestaw do wysokoczułego testu immunologicznego ^® z ludzkim heterodimerem IL-17A/F,
• description: Used for ultrasensitive quantification of Human IL-17A/F Heterodimer in human serum and plasma
• product line: SMC^®
• usage: kit sufficient for 96 wells
• species reactivity: human
• technique(s): single molecule counting: suitable
• input: serum; plasma (K2 EDTA)
• UniProt accession no.: Q16552
• compatibility: for use with TM="FemtoQuest"] and SMCxPRO^® instruments
• shipped in: wet ice
• storage temp.: 2-8°C

Opis

General description

Interleukin-17A/F (IL-17A/F) is a heterodimeric cytokine formed by the combination of IL-17A and IL-17F subunits, both of which are produced primarily by Th17 cells. This cytokine plays a significant role in mediating inflammatory responses and is involved in the recruitment of neutrophils and other immune cells to sites of inflammation. IL-17A/F is implicated in various autoimmune diseases and chronic inflammatory conditions, highlighting its potential as a therapeutic target for managing such disorders.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

• Specific Detection of IL-17A/F Heterodimer: Enables accurate quantification of the biologically distinct IL-17A/F complex, which plays a unique role in Th17-mediated inflammation and autoimmune disease.
• Ultra-Sensitive Quantification via SMC^®Technology: Supports early detection of immune activation, especially in diseases where IL-17A/F is present at low levels, such as psoriasis, multiple sclerosis, and IBD.
• Verified for Human Serum and Plasma: Demonstrates high recovery rates (88–101%) in spiked human samples.

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 2,340 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 590-600,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 106% Plasma: 111%
• Recovery: Serum: 101% Plasma: 88%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although IL-17A/F Heterodimer was detectable in non-human primates, monkey and canine samples, the assay has not been verified for these species.

Legal Information

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

O ile nie określono inaczej w naszym katalogu lub innej dokumentacji firmy dołączonej do produktu(-ów), nasze produkty są przeznaczone wyłącznie do użytku badawczego i nie mogą być wykorzystywane do żadnych innych celów, w tym między innymi do nieautoryzowanych zastosowań komercyjnych, zastosowań diagnostycznych in vitro, zastosowań terapeutycznych ex vivo lub in vivo lub jakiegokolwiek rodzaju konsumpcji lub zastosowania u ludzi lub zwierząt.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS08
• signalword: Danger
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• hcodes: H302 + H332,H311,H319,H360FD,H412,EUH430
• pcodes: P201 - P202 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B