W4262

1400W dihydrochloride

>98%, solid

• Synonim(y): N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
• Wzór empiryczny (zapis Hilla): C₁₀H₁₅N₃ · 2 HCl
• Numer CAS: 214358-33-5
• Masa cząsteczkowa: 250.17
• Numer MDL: MFCD03428622
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24278778
• NACRES: NA.77

Właściwości

• Próba: >98%
• Formularz: solid
• warunki przechowywania: desiccated
• inicjator: GlaxoSmithKline
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
• InChI: 1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
• Klucz InChI: WDJHSQZCZGPGAA-UHFFFAOYSA-N
• informacje o genach: human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Opis

Zastosowanie

1400W dihydrochloride has been used:

• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat[1]
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction[2]
• to study its efficacy on renal ischemia/ reperfusion injury in rats[3]
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation[4]

Działania biochem./fizjol.

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Cechy i korzyści

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)