V1880

[deamino-Pen¹, O-Me-Tyr², Arg⁸]-Vasopressin

≥97% (HPLC)

• Wzór empiryczny (zapis Hilla): C₄₉H₇₀N₁₄O₁₂S₂
• Numer CAS: 67269-08-3
• Masa cząsteczkowa: 1111.30
• NACRES: NA.32
• PubChem Substance ID: 24900721
• UNSPSC Code: 51111800
• MDL number: MFCD00076745
• Form: powder
• Assay: ≥97% (HPLC)

Właściwości

• sterility: non-sterile
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 0.5 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: COc1ccc(CC2NC(=O)CC(C)(C)SSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc3ccccc3)NC2=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C49H70N14O12S2/c1-49(2)24-40(67)57-32(22-28-13-15-29(75-3)16-14-28)43(70)60-33(21-27-9-5-4-6-10-27)44(71)58-31(17-18-37(50)64)42(69)61-34(23-38(51)65)45(72)62-35(26-76-77-49)47(74)63-20-8-12-36(63)46(73)59-30(11-7-19-55-48(53)54)41(68)56-25-39(52)66/h4-6,9-10,13-16,30-36H,7-8,11-12,17-26H2,1-3H3,(H2,50,64)(H2,51,65)(H2,52,66)(H,56,68)(H,57,67)(H,58,71)(H,59,73)(H,60,70)(H,61,69)(H,62,72)(H4,53,54,55)
• InChI key: HNOGCDKPALYUIG-UHFFFAOYSA-N
• Gene Information: human ... AVPI1(60370) ; mouse ... AVPI1(69534) ; rat ... AVPI1(171386), LOC689723(689723)

Opis

Application

[Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin was used to inhibit the V1 receptor, and study the role of arginine vasopressin receptors V1 and V2 on brain damage, brain edema formation and functional outcome after transient focal cerebral ischemia.[1]

Biochem/physiol Actions

[Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin is a V1 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.[2] It also stimulates three acid-base transporters and hence increases the capability of the cell to regulate pHi.[3]

Preparation Note

[deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin dissolves in water at 0.5 mg/ml to yield a clear, colorless solution.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• pcodes: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves