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T8575

Sigma-Aldrich

Anti-Tryptophan Hydroxylase antibody produced in sheep

affinity isolated antibody, buffered aqueous glycerol solution

Synonim(y):

Anti-TPH

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About This Item

Numer MDL:
MFCD00282500
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

sheep

Poziom jakości

200

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous glycerol solution

zastosowanie

sufficient for 10 blots

reaktywność gatunkowa

mammals, human

metody

western blot: 1:1,000 using human dorsal raphe nucleus

numer dostępu UniProt

P17752

Warunki transportu

wet ice

temp. przechowywania

−20°C

informacje o genach

human ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)

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Opis ogólny

The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.

Immunogen

recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.

Zastosowanie

Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:
  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence
  • immunoperoxidase staining

Działania biochem./fizjol.

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

Postać fizyczna

Solution in 150 mM NaCl, 10 mM HEPES, pH 7.5, 100 μg per mL BSA, and 50% glycerol.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Numer produktu
Opis
Cennik

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Rachel A Walker et al.
The European journal of neuroscience, 51(3), 866-880 (2019-08-04)
Aversive, positive prediction error (+PE) provides a mechanism to update and increase future fear to uncertain threat predictors. The ventrolateral periaqueductal grey (vlPAG) has been offered as a neural locus for +PE computation. Yet, a causal demonstration of vlPAG +PE
Matthew W Hale et al.
Journal of chemical neuroanatomy, 41(4), 219-226 (2011-06-07)
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different genes, tph1 and tph2, have been identified. The tph1 isoform is expressed in peripheral tissues, whereas tph2 is brain
Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition.
Ruocco AC
Neuropsychology, 30, 18-27 (2016)
R C Drugan et al.
Neuroscience, 253, 221-234 (2013-09-04)
Prior adverse experience alters behavioral responses to subsequent stressors. For example, exposure to a brief swim increases immobility in a subsequent swim test 24h later. In order to determine if qualitative differences (e.g. 19°C versus 25°C) in an initial stressor
Mahsa Moaddab et al.
Scientific reports, 10(1), 18035-18035 (2020-10-24)
Early adolescent adversity increases adult risk for anxiety disorders. The ventrolateral periaqueductal gray (vlPAG) and neighboring dorsal raphe (DR) are integral to threat prediction, and are responsive to acute stressors. Here, we tested the hypothesis that early adolescent adversity reshapes
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