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T6568
Tyrphostin RG 13022
≥98%
Synonim(y):
2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C16H14N2O2
Numer CAS:
Masa cząsteczkowa:
266.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98%
form
solid
potency
IC50 (3 micromolar for inhibition of EGF-receptor.)
mp
114-115 °C
solubility
DMSO or ethanol: soluble
storage temp.
2-8°C
SMILES string
COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2
InChI
1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
InChI key
DBGZNJVTHYFQJI-UHFFFAOYSA-N
Biochem/physiol Actions
Non-phenolic tyrphostin-class tyrosine kinase inhibitor.
Preparation Note
Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice[1].
Tyrphostin RG 13022 is soluble in DMSO and ethanol.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
S Takahashi et al.
Archives of physiology and biochemistry, 110(1-2), 34-41 (2002-04-06)
Estrogen stimulates the proliferation of pituitary cells, in particular mammotrophs. The present study was designed to clarify involvement of transforming growth factor alpha (TGF-alpha) in the estrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR
L F Gulli et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7(2), 173-178 (1996-02-01)
A431 cells overexpress epidermal growth factor receptors (EGF-Rs) and are inhibited by EGF. We show that treatment of A431 cells with 10 nM EGF induced a 15-fold increase in EGF-R autophosphorylation, leading to inhibition of cell proliferation and morphological features
W Xian et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 6(11), 1447-1455 (1995-11-01)
The present study was designed to further investigate the role of the epidermal growth factor receptor (EGFr) in mouse skin tumor promotion by evaluating the status of the EGFr in tumor promoter-treated mouse epidermis and in mouse skin tumors. Female
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| T6568-1MG | 04061826133248 |
| T6568-5MG | 04061832452647 |