T1815

Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody produced in mouse

clone 22221, purified immunoglobulin, lyophilized powder

• Synonim(y): Anti-TNF RII, Anti-TNFRSF1B
• Numer MDL: MFCD01633483
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: 22221, monoclonal
• Formularz: lyophilized powder
• reaktywność gatunkowa: human
• metody: immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood lymphocytes; microarray: suitable; neutralization: suitable
• izotyp: IgG2a
• numer dostępu UniProt: P01375
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... TNF(7124)

Opis

Opis ogólny

The tumor necrosis factor super family (TNFSF) consists of at least 19 transmembrane proteins with soluble forms that are generated by proteolysis. The biological effects of TNF are mediated by either type I or type II receptors. Type I receptors that are ubiquitously present on all cells whereas type II receptors are expressed only on cells of immune system (monocytes, macrophages, Langerhans cells) and endothelial cells. Receptors of TNFSF such as TNFR I and Fas have their own death domains that activate the apoptosis. Other receptors such as TNFR II do not have death domains and utilize TNF associated factors (TRAFs) to activate intracellular signaling. TNFR II activates NF-κB pathway via the activation of NIK. Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody recognizes human TNFR II.

Specyficzność

The antibody neutralizes the biological effect of recombinant human TNF RII. It does not neutralize or cross-react with TNF RI.

Immunogen

recombinant human tumor necrosis factor receptor II, expressed in Escherichia coli.

Zastosowanie

Anti-Tumor Necrosis Factor Receptor II antibody may be used for immunocytochemistry at a working concentration of 8-25 μg/ml using human peripheral blood lymphocytes. The antibody is suitable for neutralization assays and protein microarray. The antibody was used for flow cytometry using human CD8 T cells.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Uwaga dotycząca przygotowania

Purified using protein A

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable